منابع مشابه
Functional annotation of regulatory pathways
MOTIVATION Standardized annotations of biomolecules in interaction networks (e.g. Gene Ontology) provide comprehensive understanding of the function of individual molecules. Extending such annotations to pathways is a critical component of functional characterization of cellular signaling at the systems level. RESULTS We propose a framework for projecting gene regulatory networks onto the spa...
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In biological networks of molecular interactions in a cell, network motifs that are biologically relevant are also functionally coherent, or form functional modules. These functionally coherent modules combine in a hierarchical manner into larger, less cohesive subsystems, thus revealing one of the essential design principles of system-level cellular organization and function-hierarchical modul...
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Systems approaches for understanding biological complexity and studying diseases rely on iterative and extensive characterization of genes, transcripts, proteins and their interactions, generation of hypotheses about how they functionally inter-relate within subsystems, conversion of these hypotheses into formal mathematical models and their experimental testing (Auffray et al, 2003a). In this ...
متن کاملAnnotation Parallelism in Functional Programming
One of the most attractive features and an often-heralded advantage of functional programming languages is that they are not sequential in their nature, as conventional imperative languages are. The parallelism in a functional program is implicit, and it is manifested solely through data dependencies and semantics of primitive operators. This is in contrast to more conventional parallel languag...
متن کاملFunctional Annotation of Gene Products
In recent years new technologies have been developed that allow biologists to measure the expression of thousands of genes at the same time. The amount of data generated in a single experiment presents a significant challenge for the analyst. This project concerns one aspect of the analysis, functional annotation, where one associates relevant knowledge from different biological databases with ...
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ژورنال
عنوان ژورنال: BMC Research Notes
سال: 2012
ISSN: 1756-0500
DOI: 10.1186/1756-0500-5-580